Figure 7 | Scientific Reports

Figure 7

From: Glycopolymer binds pathogenic IgM autoantibodies and pulls them into the mononuclear phagocyte system for degradation

Figure 7

Mode of action of PPSGG: the polyanionic surface of PPSGG is recognized by scavenger receptors (SR-A1) on the surface of cells of the mononuclear phagocyte system (MPS). The binding of the PPSGG/anti-HNK-1 IgM complexes triggers a receptor mediated endocytosis, forming endocytic vesicles that are further trafficked via the progressively increasing acidic environment of the endosome/lysosome pathway, resulting in the metabolism of the complexes58.

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