Figure 2

Immunohistochemistry in esophageal adenocarcinoma with expression of fetal-gut cell markers; (a) Claudin-6 expression on tumour cells, (b) glypican 3 expression on tumor cells, (c) SALL4 expression on the nucleus of the tumor cells, (d) CK7 loss of the tumour cells, (e) AFP expression on tumour cells (lymph node metastasis), (f) SMARCA2 loss of tumour cells (tumor nuclei in pale blue without expression of SMARCA2 protein and co-existing lymphocytes and other stroma cells within the tumor show preserved SMARCA2 expression).