Table 3 The anti-AChE activity of 3a–q expressed in the term of mean ± S.E

From: Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1,1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents

Compound

Ar

R

AChE mean ± S.E

% inhibition at 50 µM

IC50 (µM)

3a

4-OMe

28.12 ± 3.93

–

3b

4-Cl

59.93 ± 11.04

–

3c

4-OMe

10.68 ± 2.31

–

3d

4-Me

39.36 ± 1.56

–

3e

4-Cl

19.27 ± 3.30

–

3f

4-OMe

32.99 ± 1.86

–

3g

4-Cl

17.78 ± 2.74

–

3h

2-CH3

23.11 ± 8.61

–

3i

1-Naphthyl

39.72 ± 1.67

–

3j

4-OMe

38.83 ± 3.27

–

3k

4-Cl

27.76 ± 1.75

–

3l

4-Me

24.89 ± 5.01

–

3m

4-Cl

74.27 ± 5.86

34.81 ± 3.71

3n

2-Me

40.72 ± 2.60

–

3o

4-Me

35.58 ± 4.63

–

3p

4-Cl

21.43 ± 1.86

–

3q

1-Naphthyl

33.99 ± 2.39

–

Donepezila

–

–

–

0.079 ± 0.05

  1. Data presented here are the mean ± S.E.
  2. aPositive control.
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