Figure 2

(a) Gills after exposure to tadalafil group showing congestion of primary lamellae (C) and mild curling of secondary lamellae (arrow). (b) Gills after exposure to microplastic group showing telangictasis (T) of secondary lamellae with epithelial hyperplasia (EH) of primary gill lamellae. (c, d) Gills after exposure to tadalafil microplastic group showing telangictasis (T), sever curling (circle), shortening of secondary lamellae (double arrow) and epithelial lifting (arrow) of secondary lamellae. (e) Kidney after exposure to tadalafil group showing thrombus (star). (f) Kidney after exposure to microplastic group showing perivascular inflammatory cell infiltration (IF) and vacuolar degeneration (arrow) of renal tubules. (g, h) Kidney after exposure to tadalafil and microplastic group showing sever necrosis of hemopiotic tissue (N), perivascular inflammatory cell infiltration (IF), dilatation of Bowman’s space (arrow) hemorrhages (H) and vacuolar degeneration (arrow) of renal tubules. (I) Liver after exposure to tadalafil group showing vacuolar degeneration (star) and congestion of sinusoids (arrow). (j) Liver after exposure to microplastic group showing congestion of blood vessels (C) and sinusoids (arrow), vacuolar degeneration (star) and mild hepatic necrosis (dashed arrow). (k, l) Liver after exposure to tadalafil microplastic group showing sever necrosis (arrow) and sever vacuolar degeneration of hepatocytes (star). (h, E × 400).