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Figure 1

From: Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice

Figure 1

Time course of AKI and hepatic effects after ischemic AKI. Wild type mice were examined 4 h, 24 h, and 7 days after sham surgery (Sham) and surgery to induce ischemic AKI (AKI). Normal mice were also studied. Renal function was assessed by (A) Serum creatinine and (B) Blood urea nitrogen (BUN) (The serum creatinine and BUN data from this cohort of mice have been previously published)6,15. Hepatic effects were assessed by (C) Serum AST, (D) Serum ALT, (E) Liver glutathione (total) levels, and (F) Liver ATP. Data are mean ± SE; statistics by Student’s t-test comparing Sham versus AKI at each time point; n = 6–10 per group.

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