Figure 4 | Scientific Reports

Figure 4

From: Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice

Figure 4Figure 4

Pathway enrichment and flux analysis reveals that glycolysis, gluconeogenesis, and pentose phosphate pathway in the liver and kidney are impacted 24 h after AKI. (A) Pathway diagram including Glycolysis, Gluconeogenesis, and Pentose Phosphate Pathway, illustrating steady state and labeled carbon study results in liver. Metabolites higher (red) or lower (blue) in AKI versus Sham mouse livers at 24 h post-procedure. Analytes in gray were detectable but not significantly different in AKI versus Sham. Analytes in black were not detectable through metabolomic analysis. Differences found in labeled carbon studies are designated by §. (B) Labeled carbon study results for Glycolysis and Gluconeogenesis intermediates in liver and kidney. (C) Labeled carbon study results for Pentose Phosphate Pathway intermediates in liver and kidney. For (B) & (C), y-axes represent peak areas (arbitrary units). For both liver and kidney, n = 8 Sham, n = 8 AKI. P-value < 0.05 (*) in Sham vs AKI. Data can be found in Supplementary Tables S6 and S7, respectively.

Back to article page