Figure 6 | Scientific Reports

Figure 6

From: Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice

Figure 6Figure 6

Glutathione is depleted in the liver and kidney 24 h after AKI, but the kidney has more glutathione intermediates available than the liver. (A) Pathway diagram including Cysteine and Glutathione Metabolism, illustrating steady state and labeled carbon study results in liver. Metabolites higher (red) or lower (blue) in AKI versus Sham mouse livers at 24 h post-procedure. Analytes in gray were detectable but not significantly different in AKI versus Sham. Analytes in black were not detectable through metabolomic analysis. Differences found in labeled carbon studies are designated by §. (B) Labeled carbon study results for Glutathione Intermediates, including Amino Acids and Dipeptides in liver and kidney. y-axes represent peak areas (arbitrary units). For both liver and kidney, n = 8 Sham, n = 8 AKI. P-value < 0.05 (*) in Sham vs AKI. Data can be found in Supplementary Tables S6 and S7, respectively.

Back to article page