Table 2 Heterogeneity results of MR analysis. Total of F-statistic and R2.
exposure on outcome | IVW | MR-Egger | Total R2 (%) | Total F-statistic | ||||
|---|---|---|---|---|---|---|---|---|
Cochran’s Q | Cochran’s Q P value | P value | Cochran’s Q | Cochran’s Q P value | P value | |||
GERD on RA (discovery) | 85.57 | 2.10e−2 | 2.8e−6 | 82.52 | 2.90e−2 | 5.4e−1 | 2.82 | 282.43 |
GERD on RA (validation) | 87.04 | 1.09e−1 | 1.8e−8 | 85.92 | 1.10e−1 | 6.3e−2 | 3.29 | 280.41 |
RA(discovery) on GERD | 51.54 | 8.98e−4 | 1.2e−2 | 51.51 | 5.82e−4 | 2.6e−1 | 15.40 | 710.01 |
RA(validation) on GERD | 6.86 | 2.31e−1 | 2.3e−1 | 6.37 | 1.73e−1 | 3.5e−1 | 4.90 | 2187.7 |
