Table 3 Sensitivity analysis of adjusted GERD with risk of RA in multivariable MR analyses.
Exposure | Method | RA (discovery) | RA (validation) |
|---|---|---|---|
GERD adjusted by BMI | IVW | P = 1.31E−02 | P = 1.37E−04 |
MR-Egger | P = 1.34E−02 | P = 1.33E−04 | |
Heterogeneity | Cochrane’s Q = 1143.21 P = 6.48E−62 | Cochrane’s Q = 808.85 P = 3.78E−24 | |
Pleiotropy | Intercept = − 0.001 P = 7.46E−01 | Intercept = 0.002 P = 4.35E−01 | |
F-statistic | 8.22 | 8.17 | |
GERD adjusted by education attainment | IVW | P = 1.29E−07 | P = 5.85E−10 |
MR-Egger | P = 2.23E−07 | P = 3.68E−10 | |
Heterogeneity | Cochrane’s Q = 377.93 P = 7.10E−25 | Cochrane’s Q = 153.39 P = 1.21E−01 | |
pleiotropy | Intercept = 0.009 P = 2.62E−01 | Intercept = 0.003 P = 3.81E−01 | |
F-statistic | 15.66 | 15.7 | |
GERD adjusted by cigarettes per day | IVW | P = 4.43E−02 | P = 2.24E−02 |
MR-Egger | P = 2.18E−01 | P = 5.65E−02 | |
Heterogeneity | Cochrane’s Q = 229.31 P = 9.62E−21 | Cochrane’s Q = 151.14 P = 2.10E−09 | |
Pleiotropy | Intercept = − 0.008 P = 1.96E−01 | Intercept = 0.006 P = 5.63E−01 | |
F-statistic | 16.22 | 16.19 | |
GERD adjusted by depression | IVW | P = 6.33E−03 | P = 4.30E−02 |
MR-Egger | P = 4.42E−01 | P = 2.43E−01 | |
Heterogeneity | Cochrane’s Q = 221.17 P = 9.93E−20 | Cochrane’s Q = 167.37 P = 1.46E−09 | |
Pleiotropy | Intercept = 0.029 P = 7.54E−02 | Intercept = − 0.001 P = 6.82E−01 | |
F-statistic | 5.82 | 5.75 | |
GERD adjusted by drinks per week | IVW | P = 7.61E−03 | P = 1.13E−02 |
MR-Egger | P = 2.44E−01 | P = 1.20E−02 | |
Heterogeneity | Cochrane’s Q = 261.75 P = 6.22E−24 | Cochrane’s Q = 188.21 P = 6.70E-11 | |
Pleiotropy | Intercept = − 0.001 P = 8.98E−01 | Intercept = −0.003 P = 3.55E−01 | |
F-statistic | 29.2 | 29.42 |
