Table 2 HIV disease markers stratified by antiretroviral treatment status among participants with perinatal HIV infection.

From: Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection

Characteristic

APHIV with

P value

Early ART initiation

Delayed ART initiation

Number

45

21

 

Age at ART initiation (years)

2.4 (0.9, 3.4)

7.2 (6.7, 8.2)

 < 0.001

Overall ART duration (years)

12.8 (11.3, 13.8)

8.1 (7.8, 9.7)

 < 0.001

Cumulative NRTI exposure (years)

12.8 (11.3, 13.8)

8.1 (7.8, 9.7)

 < 0.001

Cumulative PI exposure (years)

5.1 (0.0, 10.3)

0.1 (0.0, 4.9)

0.015

Cumulative NNRTI exposure (years)

7.0 (3.4, 10.6)

6.4 (3.7, 8.1)

0.49

Cumulative INSTRI exposure (years)a

0

0

0.92

Current ART regimen

 2 different NRTIs + 1 NNRTI

21 (47%)

11 (52%)

0.74

 2 different NRTIs + 1 PI

23 (51%)

10 (48%)

 

 Otherb

1 (2%)

0 (0%)

 

Undetectable HIV RNA viral loadc

28 (64%)

12 (60%)

0.78

Current CD4+ cell count (cells/mL)

753 (558, 928)

592 (402, 795)

0.011

 < 350

5 (12%)

3 (14%)

0.76

Nadir CD4+ cell count, (cells/mL)

574 (422, 835)

457 (368, 720)

0.025

 < 350

7 (16%)

5 (24%)

0.44

History of AIDS-related illness

12 (29%)

4 (21%)

0.54

  1. Values are reported as median (25th, 75th percentile) or number (%).
  2. PI protease inhibitors, NNRTI nonnucleoside reverse transcriptase inhibitors, NRTI nucleoside reverse transcriptase inhibitors, INSTI integrase strand transfer inhibitor.
  3. aOnly one participant exposed to an integrase strand transfer inhibitor for total duration of 1.7 years.
  4. bParticipant receiving 1 NRTI + 1 PI + 1 INSTI.
  5. cDetection limit ≥ 40 viral copies/mL.
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