Table 3 Participants' absolute mean values of cardiac parameters stratified by perinatal HIV infection and antiretroviral treatment status.
Cardiac parameter | PHIV and ART status | ||||
|---|---|---|---|---|---|
HIV uninfected | APHIV with early ART initiation | APHIV with delayed ART initiation | |||
Mean (95% CI) | Mean (95% CI) | P valuea | Mean (95% CI) | P valueb | |
Number | 37 | 45 | 21 | ||
LV geometry | |||||
LVMi (g/m2) | 58.5 (54.6, 62.5) | 54.9 (52.1, 57.8) | 0.22 | 59.1 (55.5, 62.7) | 0.83 |
LVEDVi (mL/m2) | 77.5 (73.4, 83.5) | 81.3 (77.7, 85.0) | 0.12 | 86.7 (78.9, 94.5) | 0.028 |
LVESVi (mL/m2) | 28.9 (26.6, 31.2) | 30.5 (28.1, 32.8) | 0.26 | 34.5 (30.7, 38.2) | 0.019 |
Relative wall thickness | 0.34 (0.32, 0.36) | 0.34 (0.33, 0.35) | 0.95 | 0.36 (0.33, 0.38) | 0.19 |
LV systolic function | |||||
LVEF (%) | 63.0 (61.5, 64.6) | 63.0 (60.9, 65.0) | 0.83 | 60.2 (58.5, 62.0) | 0.18 |
Peak systolic strain (%) | |||||
Circumferential | −20.1 (−21.1, −19.1) | −21.5 (−22.4, −20.6) | 0.020 | −20.0 (−22.2, −19.8) | 0.23 |
Longitudinal | −15.7 (−16.3, −15.1) | −16.9 (−17.6, −16.2) | 0.041 | −16.1 (−17.2, −14.9) | 0.72 |
Radial | 33.2 (31.3, 35.1) | 34.3 (32.4, 36.3) | 0.35 | 32.5 (30.1, 34.9) | 0.52 |
Time to peak systolic strain (ms) | |||||
Circumferential | 247.4 (185.0, 309.8) | 205.3 (158.9, 251.7) | 0.56 | 227.8 (142.5, 313.1) | 0.88 |
Longitudinal | 347.6 (333.0, 362.2) | 316.3 (293.0, 339.7) | 0.034 | 343.0 (328.6, 357.3) | 0.91 |
LV diastolic function | |||||
Peak diastolic strain rate (s−1) | |||||
Circumferential | 1.41 (1.34, 1.48) | 1.40 (1.34, 1.47) | 0.86 | 1.33 (1.23, 1.44) | 0.20 |
Longitudinal | 1.09 (1.00, 1.18) | 1.12 (1.02, 1.22) | 0.67 | 1.05 (0.93, 1.17) | 0.63 |
Radial | −2.60 (−2.79, −2.42) | −2.58 (−2.74, −2.43) | 0.85 | −2.28 (−2.47, −2.10) | 0.029 |
Peak diastolic velocity (cm/s) | |||||
Circumferential | 11.7 (5.4, 17.9) | 16.1 (12.8, 19.4) | 0.17 | 14.8 (9.1, 20.4) | 0.44 |
Longitudinal | 28.8 (25.9, 31.7) | 27.1 (24.7, 29.4) | 0.37 | 27.5 (23.1, 32.0) | 0.60 |
Radial | 38.5 (36.5, 40.5) | 37.9 (36.1, 39.6) | 0.65 | 36.8 (33.5, 40.0) | 0.31 |
LV tissue composition | |||||
Native T2 (ms) | 38.8 (38.3, 39.3) | 38.4 (37.7, 39.1) | 0.16 | 38.5 (37.4, 39.5) | 0.58 |
T2 SIR | 1.59 (1.49, 1.69) | 1.53 (1.44, 1.62) | 0.69 | 1.59 (1.47, 1.70) | 0.77 |
Native T1 (ms) | 1,235 (1,222, 1,247) | 1,208 (1,197, 1,219) | 0.045 | 1,239 (1,222, 1,257) | 0.95 |
ECV fraction (%) | 28.1 (27.0, 29.1) | 28.7 (27.7, 29.7) | 0.13 | 29.5 (28.0, 31.0) | 0.044 |
Presence of LGE (%) | 57.1 (38.2, 76.1) | 52.6 (36.3, 69.0) | 0.72 | 47.1 (22.2, 71.9) | 0.52 |
LA geometry ad function | |||||
Indexed LA area (cm2/m2) | 11.2 (10.6, 11.9) | 12.4 (11.8, 13.0) | 0.016 | 11.5 (10.3, 12.7) | 0.67 |
Minimum LAVi (mL/m2) | 33.4 (30.7, 36.0) | 36.9 (32.3, 41.4) | 0.16 | 38.2 (35.6, 40.8) | 0.029 |
Maximum LAVi (mL/m2) | 13.8 (12.0, 15.6) | 14.8 (12.3, 17.3) | 0.56 | 16.0 (14.5, 17.5) | 0.056 |
LAEF (%) | 59.1 (56.0, 62.2) | 58.2 (55.6, 60.8) | 0.63 | 60.3 (56.9, 63.6) | 0.61 |
RV geometry and function | |||||
RVEDVi (mL/m2) | 77.0 (71.4, 82.5) | 83.0 (78.9, 87.0) | 0.099 | 87.0 (78.1, 95.8) | 0.029 |
RVESVi (mL/m2) | 33.3 (29.8, 36.80 | 35.4 (33.0, 37.7) | 0.34 | 37.7 (32.5, 42.9) | 0.11 |
RVEF (%) | 57.4 (55.0, 59.8) | 57.3 (55.4, 59.3) | 0.98 | 57.0 (54.3, 59.7) | 0.84 |
TAPSE (cm) | 1.4 (1.3, 1.6) | 1.8 (1.6. 2.0) | 0.005 | 1.5 (1.2, 1.8) | 0.89 |
