Figure 2 | Scientific Reports

Figure 2

From: Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin

Figure 2

Ferroptosis was implicated in BCHE-induced death of human BC cells. (a) BCHE was added to treat MCF-7 and MDA-MB-231 cells for 48 h with/without 3-methyladenine (100 nM), necrostatin-1 (10 µM), and Z-VAD-FMK (10 µM). A MTT assay was conducted to explore cell viability. (b) Both BC cell lines were subjected to 48 h of BCHE treatment with or without ferrostatin-1 (10 µM). (c) Both BC cell lines were exposed to 48 h of BCHE treatment with or without deferoxamine (10 µM). (d) KEGG analysis of representative signaling pathway enrichment between different treatment groups of MDA-MB-231 cells. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page