Figure 6 | Scientific Reports

Figure 6

From: Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin

Figure 6

Schematic diagram illustrating mechanism of BCHE in inducing ferroptosis to exert its anti-BC effect. BCHE promotes iron transport in BC cells by increasing transferrin expression, and iron accumulation triggers the Fenton reaction, causing the generation of ROS, which serve as key mediators of intracellular lipid peroxidation. Additionally, BCHE suppresses GPX4 expression in BC cells, leading to the upregulation of ROS-induced lipid peroxidation, ultimately triggering ferroptosis in BC cells.

Back to article page