Table 1 Electrocardiogram (ECG) parameters of control, bulk, and the three ZnO NP-treated groups (T1, T2, and T3).

From: Electrophysiological and biochemical effect of zinc oxide nanoparticles on heart functions of male Wistar rats

 

Animal groups

Control

Bulk

T1

T2

T3

HR (beats/min)

Mean ± SE

441 ± 6.4

434 ± 8.0

423.5 ± 2.2

414 ± 7

373.6 ± 4.2a*

% of change

A

 

 − 1.5%

 − 4%

 − 6.1%

 − 15.3%

B

  

 − 2.4%

 − 4.6%

 − 13.9%

PR interval (s)

Mean  ± SE

0.041 ± 0.004

0.048 ± 0.004a*

0.049 ± 0.003a*

0.05 ± 0.005a*

0.057 ± 0.001ab**

% of change

A

 

 + 17%

 + 19.5%

 + 21.95%

 + 39%

B

  

 + 2.08%

 + 4.16%

 + 18.75%

R-amplitude (mv)

Mean ± SE

0.358  ± 0.02

0.436 ± 0.02 a*

446 ± 0.02a*

0.46 ± 0.03a*

0.491.02a**

% of change

A

 

 + 21.7%

 + 24.6%

 + 28.5%

 + 37.15%

B

  

 + 2.14%

 + 3.13%

 + 10%

T-amplitude (mv)

Mean ± SE

0.258 ± 0.02

0.259 ± 0.03

0.26 ± 0.02

0.266 ± 0.02

0.283 ± 0.016

% of change

A

 

 + 0.4%

 + 0.8%

 + 3.1%

 + 9.7%

B

  

 + .38%

 + 2.7%

 + 9.2%

  1. A: percentage of change compared to the control group.
  2. B: percentage of change compared to the bulk group.
  3. HR heart rate, PR interval conduction time, R-amplitude depolarization voltage, T-amplitude repolarization voltage, ZnO NPs zinc oxide nanoparticles, ZnO NP-treated groups T1: 25 mg/kg BW, T2: 50 mg/kg BW, T3: 100 mg/kg BW, Bulk ZnO bulk treated group (100 mg/kg BW), SE standard error.
  4. *p < 0.05, **p < 0.001, ***p < 0.0001 compared to the control group.
  5. Values are shown as mean ± SE (n = 6), and the superscripts in different letters represent the following: asignificant compared to the respective control group, bsignificant compared to the bulk group.