Figure 4

Total IgG and HPV16-IgG results in FVU of the IgG enrichment cohort. (A) Boxplots of total human IgG concentrations after different enrichment protocols for 11 FVU samples using the BioPlex, the HTRF assay and the AlphaLISA. (B) Boxplots of HPV16-IgG concentrations after different enrichment protocols for 11 FVU samples. Significance levels are represented in the figure by an asterisk (*p < 0.05, **p < 0.01, ***p < 0.001). Different symbols represent different IDs. Results for TRF based methods (HTRF and DELFIA) are invalid for PGMB enrichment methods due to non-specific binding.