Table 1 Characteristics of the study population. Data are presented as median (25th–75th percentile), if not indicated otherwise. Metric variables were compared with Mann–Whitney-U-test and categorial variables with Pearson-Chi-Square test.
Healthy controls (n = 29) | Septic shock (n = 89) | Septic shock survivors (n = 48) | Septic shock non-survivors (n = 41) | P value survivors vs. non survivors | |
|---|---|---|---|---|---|
Age (years) | 28 (26–42) | 63 (52–73) | 62 (49–74) | 63 (58–72) | 0.242 |
Sex (% male) | 48.3 | 70.8 | 68.8 | 73.2 | 0.648 |
APACHE II | 26 (20.5–32.5) | 23 (19–27) | 30 (25–37) | < 0.001 | |
SAPS II | 52 (40.5–71.5)) | 47 (36–56) | 68 (51–80) | < 0.001 | |
SOFA d1 | 11 (7–14) | 10 (8–13) | 14 (12–17) | < 0.001 | |
SIRS d1 | 3 (2–3) | 3 (2–3) | 3 (2–4) | 0.119 | |
SOFA max | 13 (9–17) | 11 (8–13) | 17 (13–19.5) | < 0.001 | |
Mechanical ventilation (%) | 60.7 | 39.6 | 85.4 | < 0.001 | |
Renal replacement therapy (%) | 42.7 | 22.9 | 65.9 | < 0.001 | |
CRP max (mg/dl) | 25.1 (18.6–33.5) | 25.0 (18.8–34.8) | 25.1 (15.9–33.5) | 0.672 | |
PCT max (µg/l) | 18.4 (4.2–76.4) | 24.8 (6.3–74.0) | 12.4 (2.6–81.6) | 0.426 | |
Creatinine max (mg/dl) | 2.30 (1.48–3.51) | 1.92 (1.45–3.33) | 2.32 (1.55–3.64) | 0.451 | |
Leukocytes max (G/l) | 17.0 (4.2–76.8) | 17.2 (9.5–23.4) | 16.0 (2.8–25.8) | 0.446 | |
Lactate max (mg/dl) | 30.0 (21.0–63.0) | 23.0 (18.0–39.0) | 60.0 (27.0–134.0) | < 0.001 | |
VIS max | 23.3 (11.5–62.5) | 16.0 (7.8–27.9) | 58.9 (26.0–177.6) | < 0.001 | |
INR max | 1.5 (1.3–1.9) | 1.4 (1.3–1.7) | 1.7 (1.3–1.9) | 0.034 | |
Primary sepsis focus (site: %) | Lung: 48.3 | Lung: 54.2 | Lung: 41.5 | ||
Abdomen: 18.0 | Abdomen: 16.7 | Abdomen: 19.5 | |||
Blood: 15.7 | Blood: 12.5 | Blood: 19.5 | |||
Urinary tract: 11.2 | Urinary tract: 10.4 | Urinary tract: 12.2 | |||
Skin/soft tissue: 6.7 | Skin/soft tissue: 6.3 | Skin/soft tissue: 7.3 | |||
Positive blood culture (%) | 58.4 | 60.4 | 56.1 | 0.68 |
