Table 4 List of NAT genes located within experimentally characterized biosynthetic gene clusters (BGCs), identified via interrogation of the MIBiG database.
Organism scientific name | NAT gene | NAT protein ID (NCBI) | Proposed NAT functiona | BGC type | BGC ID (MIBiG) | BGC product | BGC product activityb | References |
|---|---|---|---|---|---|---|---|---|
Amycolatopsis mediterranei strain S699 | NAT3 rifF | AAC01715.1 | Amide synthase (polyketide cyclization) | PKS | Rifamycin | Antimicrobial | ||
Salinispora arenicola strain CNS-205 | NAT sare_1251 | ABV97156.1 | Amide synthase (polyketide cyclization) | PKS | Rifamycin | Antimicrobial | ||
Streptomyces sp. strain CS | NAT natF | ADM46361.1 | Amide synthase (polyketide cyclization) | PKS | Naphthomycin A | Antimicrobial, antitumor | ||
Streptomyces sp. strain HKI0576 (Streptomyces sp. strain W112) | NAT divN | CCP20052.1 | Amide synthase (polyketide cyclization) | PKS | Divergolide A-D | Antimicrobial, antitumor | ||
Streptomyces sp. strain LZ35 | NAT hgcF | AFV30252.1 | Amide synthase (polyketide cyclization) | PKS | Hygrocin A,B | Antimicrobial, antitumor | ||
Streptomyces leeuwenhoekii strain C34 | NAT2 cxmF | CQR60492.1 | Amide synthase (polyketide cyclization) | PKS | Chaxamycin A-D | Antimicrobial, antitumor | ||
Amycolatopsis sp. strain Hca4 | NAT rmpF | AWH12663.1 | Amide synthase (polyketide cyclization) | PKS | Rifamorpholine A-E | Antimicrobial | ||
Streptomyces spectabilis strain CCTCC M2017417 | stvF | ASZ00152.1 | Amide synthase (polyketide cyclization) | PKS | Streptovaricin | Antimicrobial | ||
Amycolatopsis vancoresmycina strain NRRL B-24208 | NAT5 kngF | WP_004559807.1 | Amide synthase (polyketide cyclization) | PKS | Kanglemycin A,V1,V2 | Antimicrobial | ||
Streptomyces achromogenes subsp. rubradiris strain NRRL 3061 | rubF | CAI94702.1 | Amide synthase (polyketide cyclization) | PKS | Rubradirin | Antibiotic | ||
Actinosynnema pretiosum subsp. auranticum strain ATCC 31565 | asm9 | AAM54087.1 | Amide synthase (polyketide cyclization) | PKS | Ansamitocin P-3 | Antitumor | ||
Actinosynnema pretiosum subsp. pretiosum strain ATCC 31280 | NAT3 ansa11 | AQZ37096.1 | (–) (asm9 of BGC0000020, 97% identity/ 99.6% coverage) | PKS | Ansamitocin P-3 | Antitumor | ||
NAT2 mbcF | ACF35448.1 | Amide synthase (polyketide cyclization) | PKS | Macbecin | Antitumor | |||
Streptomyces hygroscopicus strain NRRL 3602 | gdmF | AAO06919.1 | Amide synthase (polyketide cyclization) | PKS | Geldanamycin | Antitumor | ||
Streptomyces hygroscopicus subsp. duamyceticus strain JCM4427 | gelD | ABB86411.1 | (–) (gdmF of BGC0000066, 100% identity/ 100% coverage) | PKS | Geldanamycin | Antitumor | ||
Streptomyces hygroscopicus 17997 | gdmF | ABI93780.1 | Amide synthase (polyketide cyclization) | PKS | Geldanamycin | Antitumor | ||
Micromonospora sp. strain HK160111 | NAT mas10 | ATY46593.1 | Amide synthase (polyketide cyclization) | PKS | Microansamycins A-I | Unknown | ||
Amycolatopsis alba strain DSM 44262 | NAT1 asc9 | WP_020636846.1 | Amide synthase (polyketide cyclization) | PKS | Ansacarbamitocin A | Antibiotic | ||
Streptomyces nodosus subsp. asukaensis strain ATCC 29757 | asuC2 | ADI58636.1 | N-acyltransferase | T2PKS | Asukamycin | Antimicrobial, antitumor | ||
Streptomyces aureus SOK1/5-04 | NAT colC2 | AIL50169.1 | N-acyltransferase | T2PKS | Colabomycin E | Anti-inflammatory, antibiotic | ||
Streptomyces platensis MA7327 | ptmC | ACO31290.1 | Arylamine N-acyltransferase (substrates: ADHBA and platensicyl-CoA or platencinyl-CoA) | Terpene | Platensimycin, platencin | Antibiotic | ||
Streptomyces platensis MA7339 | ptnC | ADD82996.1 | Arylamine N-acyltransferase (substrates: ADHBA and platencinyl-CoA) | Terpene | Platencin | Antibiotic | ||
Streptomyces albus subsp. chlorinus strain LW030448 (NRRL B-24108) | nybK | AYV61412.1 | Arylamine N-acyltransferase (substrates: acetoacetyl-CoA and 2,6-diaminophenol) | Other | Nybomycin | Antibiotic | ||
Streptomyces sp. F001 | NAT2 daqS | RZB16698.1 | Arylamine N-acyltransferase (substrates: 2,6-DAHQ and β-ketoacyl-CoA) | Other | Diazaquinomycin A,E,F,G | Antibiotic, antitumor | ||
NAT3 daqT | RZB16697.1 | |||||||
Micromonospora sp. B006 | NAT1 daqS | AXO35214.1 | Arylamine N-acyltransferase (substrates: 2,6-DAHQ and β-ketoacyl-CoA) | Other | Diazaquinomycin H,J | Antibiotic | ||
NAT2 daqT | AXO35215.1 | |||||||
Actinomyces sp. Lu 9419 | NAT cetD | ABL74384.1 | Aminocyclitol N-acetyltransferase | Cyclitol | Cetoniacytone A | Antitumor | ||
Streptomyces sp. NRRL B-1347 | NAT2 gilW | WP_030684641.1 | Putative N-acetyltransferase | Other | Gilvusmycin | Antibiotic, antitumor | ||
Archangium disciforme Angiococcus disciformis An d48 | NAT tubG | CAF05656.1 | O-acyltransferase | NRPS–PKS | Tubulysin A | Cytotoxic, anticancer | ||
Streptomyces sp. RI18 | NAT bezG | BBC27534.1 | O-acetyltransferase (substrates: PHABA and acetyl-CoA), essential for the formation of the bicyclic scaffold found in the final product | Other | Benzastatin derivatives | Antioxidant | ||
Streptomyces murayamaensis sp. nov. Hata et Ohtani | NAT orf3 | AAO65324.1 | (–) (bezG of BGC0001529, 47.0% identity/97.8% coverage) | PKS | Kinamycin | Antimicrobial, antitumor | ||
Streptomyces griseoruber strain Sgr29 | NAT orf2 | AQW35032.1 | (–) (nybK of BGC0001965, 40% identity/100.4% coverage) | PKS | Murayaquinone | Antibiotic | ||
NAT orf23 | AQW35053.1 | (–) (orf3 of BGC0000236, 43% identity/92.5% coverage) |
