Figure 11
From: Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents
PLX3397 mitigated the increase in ductular reaction, fibrosis and ER stress in the liver of GWI mice binging on EtOH. (A) Representative images of CK19 IHC in livers of GWI mice treated with vehicle, EtOH or EtOH + PLX. (B) Image analysis quantification of CK19 IHC. Markers of fibrosis such as collagens and other ECM proteins were stained with Sirius Red: images (C) and quantification (D) are shown. αSMA, as indicator of HSC activation, was tested by IHC; images and quantification of αSMA IHC are shown in panels (E) and (F), respectively. N = 4, p < 0.05. #, vs GWI control; $, vs GWI + EtOH. Scale bar, 50 µm.
