Table 3 Linear model on the association of PGS and coffee drinking with AAO in the PD study group.

From: The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson’s disease

 

Estimate

Standard error

p value

Coffee drinking (binary) (n = 139)1

 Intercept

56.9608

1.9194

 < 2 × 10–16*

 PGS

− 1.3514

0.6955

0.0541

 Coffee drinking (binary)

1.1929

1.8383

0.5175

 Sex (male)

3.4321

1.6566

0.0402*

 PC1

− 8.3114

71.1118

0.9071

 PC2

− 28.5586

56.6419

0.6150

Coffee drinking dosage (n = 139)1

 Intercept

58.1752

1.6649

 < 2 × 10–16*

 PGS

− 1.2006

0.7056

0.0912

 Coffee drinking dosage

− 0.0414

0.0816

0.6125

 Sex (male)

3.7245

1.6396

0.0247*

 PC1

− 56.0175

67.0364

0.4049

 PC2

− 37.4508

57.1142

0.5131

Coffee drinking duration (n = 100)1

 Intercept

55.3345

1.8344

 < 2 × 10–16*

 PGS

− 1.0068

0.8288

0.2275

 Coffee drinking duration

0.1840

0.0432

5 × 10–5*

 Sex (Male)

− 1.1479

1.8432

0.5349

 PC1

101.8483

84.7233

0.2323

 PC2

− 79.4870

60.2628

0.1904

Coffee drinking (binary) (n = 138)2

 Intercept

57.3700

2.0912

 < 2 × 10–16*

 PGS

− 2.3622

1.4141

0.0972

 Coffee drinking (binary)

0.9643

2.2095

0.6632

 Sex (male)

3.1499

1.6543

0.0591

 PC1

− 13.5675

70.8490

0.8484

 PC2

− 9.0768

57.0590

0.8739

 PGS:Coffee drinking (binary)

1.0425

1.6328

0.5243

Coffee drinking dosage (n = 139)2

 Intercept

58.5453

1.7536

 < 2 × 10–16*

 PGS

− 1.7430

1.0617

0.1030

 Coffee drinking dosage

− 0.0759

0.0960

0.4305

 Sex (male)

3.6559

1.6459

0.0280*

 PC1

− 53.6120

67.2625

0.4269

 PC2

− 36.9398

57.2335

0.5198

 PGS:Coffee drinking dosage

0.0595

0.0869

0.4948

Coffee drinking duration (n = 100)2

 Intercept

55.4035

1.9016

 < 2 × 10–16*

 PGS

− 1.1151

1.1070

0.3164

 Coffee drinking duration

0.1797

0.0522

0.0009*

 Sex (male)

− 1.1331

1.8555

0.5429

 PC1

103.6788

86.0536

0.2313

 PC2

− 79.7335

60.6014

0.1915

 PGS:Coffee drinking duration

0.0062

0.0419

0.8822

  1. PGS polygenic score; AAO age at onset; PD Parkinson’s disease; PC principal component; glm generalized linear model.
  2. *p value < 0.05 are highlighted in bold.
  3. 1glm(formula = AAO ~ PGS + Coffee drinking + Sex + PC1 + PC2, family = gaussian, data = data).
  4. 2glm(formula = AAO ~ PGS * Coffee drinking + Sex + PC1 + PC2, family = gaussian, data = data).
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