Figure 6
From: AI driven analysis of MRI to measure health and disease progression in FSHD
Examples of the five different types of fat distribution and progression for several different muscles. For each type, the right 3D models are the pixel-by-pixel fat fraction, in which each pixel is color coded based on fat fraction (%) from 0% (blue) to 100% (yellow). The left most muscle is at baseline, and the right most is after 1 year. The total fat fraction (%) for the entire muscle volume is given in black. Next, provided is the cross-sectional area (CSA) graphs for contractile muscle (red/pink) and fat (yellow) along the length of the muscle (distal to proximal, %) at baseline (solid line) and 1 year later (dotted line). After, the fat fraction (%) along the CSA is provided as a function of location along the muscle at baseline (solid line) and 1 year later (dotted line). Lastly, the frequency in which each pixel’s fat fraction is found is displayed as a histogram from 0% fat fraction to 100% fat fraction at baseline (solid line) and 1 year later (dotted line). All CSAs are illustrated from 10 to 90% along the muscle to avoid potential over interpretation of change in CSA from small areas at the ends of the muscle. Note—the contractile and fat CSA plots contain a light cloud that indicated ± 5% error; and the fat fraction plot contains a light cloud to indicate ± 2.5% error.
