Figure 1 | Scientific Reports

Figure 1

From: Prognostic relevance of high expression of kynurenine pathway markers in glioblastoma

Figure 1

Simplified illustration of the kynurenine pathway (KP). Kynurenine and kynurenic acid are endogenous ligands of the aryl hydrocarbon receptor (AhR). Solid lines with multiple arrowheads symbolize the step-by-step involvement of additional enzymes. Dotted lines indicate the activation of AhR by kynurenine and kynurenic acid. The activation of AhR by kynurenine ligands is believed to mediate immunosuppression. Created with BioRender.

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