Figure 5

Distribution of genomic alterations among LSES and MHSES patients with gastric adenocarcinoma. The red color indicates copy number amplification. The green color indicates copy number deletion. The blue color indicates copy number loss. According to copy number variation (CNV) analysis, both SE groups displayed similar levels of CNV with amplification. Interestingly, CNVs with amplification were more frequently found in the MYC gene in MHSES patients, whereas EGFR mutations were more common in LSES patients. MHSES patients exhibited deletions only in the CDH1 gene, while LSES patients displayed deletions in CDH1, PARK2, PIK3R1 and RNF43 genes. MHSES patients were more likely to demonstrate CNV loss than LSES patients (n = 6 vs. n = 4), with both groups showing mutations in CDKN2A, CDKN2B, and SMAD4 genes.