Figure 1
From: Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection
Single-cell RNA sequencing reveals a characteristic immune cell landscape in the ascending aorta in patients with Stanford type A acute aortic dissection (AAD). (A) Representative contrast-enhanced computed tomography (CT) image of Stanford type A AAD. (B) Histological images stained with hematoxylin and eosin (HE) and Elastica van Gieson (EVG). (C,D) Uniform manifold approximation and projection (UMAP) dimensionality reduction analysis identifying a unique single-cell immune landscape in the aortas of combined (C) and each individual Control or AAD group (D) (n = 3 Controls from Li et al.24; n = 2 AAD). (E) Dot plots displaying signature cell gene expression markers for each immune cell cluster. (F) Comparison of the proportions of each cluster between controls and patients with AADs.
