Table 1 Structures and IC50 values of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives 5a–n against α-glucosidase.

From: Design, synthesis, in vitro, and in silico anti-α-glucosidase assays of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents

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Compound

R

IC50 (µM)

5a

H

62.9 ± 0.3

5b

3-Me

63.6 ± 1.1

5c

4-Me

42.6 ± 0.9

5d

2,3-Dimethyl

66.0 ± 1.8

5e

2,6-Dimethyl

110.8 ± 1.6

5f

4-Et

40.2 ± 1.6

5g

4-OMe

83.0 ± 0.7

5h

3-Cl

311.3 ± 2.4

5i

4-Cl

83.0 ± 1.6

5j

2,4-Dichloro

39.6 ± 1.4

5k

4-Br

26.8 ± 0.5

5l

3-NO2

110.3 ± 0.6

5m

4-NO2

78.8 ± 0.3

5n

2-Me-4-NO2

43.5 ± 0.7

Acarbose

–

752.0 ± 2.0

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