Figure 2
From: Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells
The epitope binning assay- comparison between VHH-H2/D8/B11 and Repatha by SPR. The epitope binning assay consists of four steps: chip capturing; binding PCSK9 to saturation; adding secondary antibody; Protein A chip regeneration. (A) It shows the binding-epitope differences between VHH-H2/D8/B11 and Repatha by SPR. (B) It shows the binding-epitope differences between VHH-H2/D8 and VHH-B11 by SPR. The horizontal axis represents the timeline. The vertical axis represents the relative response unit.
