Figure 2

Synthesis of 2,4-disubstituted quinazoline derivatives 6a–j. Reagents and conditions: (a) 190 °C, 24 h; (b) POCl3, N,N-diethylaniline, 115 °C, 16 h; (c) EtOH, reflux, 24 h.

Synthesis of 2,4-disubstituted quinazoline derivatives 6a–j. Reagents and conditions: (a) 190 °C, 24 h; (b) POCl3, N,N-diethylaniline, 115 °C, 16 h; (c) EtOH, reflux, 24 h.