Figure 2
From: Exploring the globoid cell leukodystrophy protein network and therapeutic interventions
Identification of physiologic-neurobiological process of differentially expressed genes. (a) Neurological processes involved in the brain development were significantly affected. 1 biological regulation, 2 system development, 3 cell differentiation, 4 nervous system development, 5 cell development, 6 neurogenesis, 7 neuron differentiation, 8 cell–cell signaling, 9 neuron development, 10 axon development, 11 axonogenesis, 12 nerve development, 13 neural crest cell differentiation. (b) Heat map presenting the protein node scores. ASPL average shortest path length, BC BetweennessCentrality, CC ClosenessCentrality, EC EdgeCount, ID Indegree, NC neighborhood connectivity, OD Outdegree, St stress, IC integrated centrality. (c) Heat map presenting the gene expression of differentially expressed genes based on fragments per kilobase of transcript per million mapped reads. Genes traced in the Search Tool for the Retrieval of Interacting Genes/Proteins with at least one interaction were evaluated.
