Figure 1
Serial mutational spectrum from ET to transformed AML. The serial mutational spectrum of each patient in the clinical course from ET to transformed AML is shown in fish plot format. Although five patients (UPN1-5) had the same CALR, MPL, or JAK2 mutation as that of ET at AML transformation, three patients (UPN6-8) in whom the JAK2V617F-mutated clone was dominant at ET showed that the dominant clones at AML transformation did not have JAK2V617F mutation.
