Table 2 Mutation status in ET and transformed AML cells.

1

CALR^K385fs*47

ASXL1^G643fs

TP53^C238S

U2AF1^Q157R

22.8

5.1

-

-

34.2

4.7

37.4

33.2

2

CALR^L367fs*43

MPL^S505N

TP53^C153Y

NRAS^Q61K

51.0

39.0

3.0

-

47.0

45.0

93.0

2.0

3

MPL^W515L

TP53^R248Q

EZH2^G660R

PHF6^G306E

75.1

14.1

18.1

27.8

88.0

83.9

40.1

-

4

JAK2^V617F

TP53^H178P

18.4

-

95.7

96.7

5

JAK2^V617F

TET2^Q1030*

TET2^C1271fs

ASXL1^E773*

RUNX1^L98fs

CEBPA^P23fs

32.5

40.3

36.0

37.3

-

-

50.1

49.6

47.6

53.1

46.6

40.8

6

JAK2^V617F

TET2^Q278*

TP53^M133K

IDH2^R140Q

NRAS^G12S

68.5

10.3

-

-

-

-

48.3

82.4

45.5

6.4

7

JAK2^V617F

TET2^R1262L

TET2^H1380Y

TP53^R280S

SRSF2^P95R

CBL^G413D

84.0

41.8

43.4

-

-

-

9.9

60.0

34.2

77.6

73.8

67.1

8

JAK2^V617F

TP53^R248W

TP53^V173L

SMARCC2^D381E

UBR4^R450H

ZNF143^S286R

40.5

4.7

4.4

50.7

47.7

47.9

2.7

87.5

3.5

47.9

48.5

60.6