Table 5 Comparison of mutation status between AML and PDX cells.

From: Initiating-clone analysis in patients with acute myeloid leukemia secondary to essential thrombocythemia

UPN

Mutation

VAF (%)

AML

PDX

1

CALRK385fs*47

34.2

40.2

ASXL1G643fs

4.7

-

TP53C238S

37.4

99.9

U2AF1Q157R

33.2

49.5

8

JAK2V617F

2.7

-

TP53R248W

87.5

98.7

TP53V173L

3.5

-

SMARCC2D381E

47.9

44.8

UBR4R450H

48.5

50.4

ZNF143S286R

60.6

52.2

  1. - indicates not detected
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