Table 2 Clinical data in the exploration and replication cohorts (left and right, respectively), in each case comparing Groups 1 and 2 as defined by hierarchical cluster analysis in each cohort.

From: Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy

 

Exploration cohort

Replication cohort

Group 1

Group 2

P-value

Group 1

Group 2

p-value

Age (years)

69 (61–76)

71 (64–78)

0.179

70(61–73)

74(68–78)

0.003*

Sex (% females)

33%

30%

0.764

29%

30%

0.911

BMI (kg/m2)

28.1 (24.3–33.3)

29.4 (26.6–35.3)

0.164

29.1 (27.0–32.4)

29.0 (26.5–32.3)

0.637

HbA1c%

7.4 (7.0–8.8)

7.5 (6.6–8.4)

0.343

7.9 (6.6–8.7)

7.3 (6.6–8.1)

0.550

Painful neuropathy (%)

44%

50%

0.603

45%

52%

0.510

TCSS

8.5 (6–12)

11 (8–15)

0.027*

10 (8.5–12)

12.5(9–14)

0.016*

DN4

3 (1–5.5)

4(2–5)

0.291

4(1–5.5)

4(2.5–6)

P = 0.292

  1. Data are expressed as median (25th–75th percentiles) unless specified otherwise.
  2. BMI, body mass index; TCSS, Toronto Clinical Scoring System; DN4, Douleur Neuropathique en 4 Questions.
  3. *Denotes statistical significance at the 0.05 level.
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