Table 4 Top 22 proteins* associated with Toronto Clinical Scoring System (TCSS) in OPLS model.

From: Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy

Proteins associated with TCSS (n = 186)

p(corr) with TCSS as Y-variable

Is this protein also part of the top 22 proteins of the exploration cohort?

Is this protein also part of the top 22 proteins of the replication cohort?

EDA2R

0.64

Yes ☑

No

TNFRSF12A

0.62

Yes ☑

Yes ☑

SCARB2

0.62

Yes ☑

Yes ☑

N2DL-2

0.59

Yes ☑

Yes ☑

SKR3

0.59

Yes ☑

Yes ☑

EFNA4

0.58

Yes ☑

Yes ☑

LAYN

0.56

Yes ☑

Yes ☑

CLM-1

0.55

No

No

CD38

0.54

Yes ☑

No

UNC5C

0.52

Yes ☑

Yes ☑

GFR-alpha-1

0.51

Yes ☑

Yes ☑

JAM-B

0.50

Yes ☑

Yes ☑

CLM-6

0.48

No

Yes ☑

Beta-NGF

0.46

No

No

CDH3

0.46

Yes ☑

Yes ☑

SMOC2

0.44

Yes ☑

No

SCARA5

0.42

Yes ☑

Yes ☑

MSR1

0.42

No

No

TNFRSF21

0.42

Yes ☑

Yes ☑

VWC2

0.42

Yes ☑

No

ADAM 22

0.42

Yes ☑

Yes ☑

THY 1

0.40

Yes ☑

Yes ☑

  1. p(corr) values are all positive, corresponding to positive correlations with TCSS. Included in the table is also an illustration of the overlap with the top 22 proteins of the two previous OPLS-DA models according to Table 3 (exploration and replication), see the two columns furthest to the right.
  2. *Note: To enable a comprehensive comparison with the exploration and replication cohorts, 0.4 was here chosen as cut-off value for |p(corr)|, rendering a list of 22 proteins listed in falling order of p(corr). However, consistently with the pre-defined cut-off value of 0.5 (see “Methods”), the main findings of the study are the 11 proteins with |p(corr)|of at least 0.5, excluding EDA2R, see text.
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