Table 3 Drug doses by model.
From: Entinostat as a combinatorial therapeutic for rhabdomyosarcoma
Component/RMS model | CTG-1008 (Alias: CF-00071) | CTG-1916 (Alias: CF-01513) | CTG-2127 | CTG-1213 (Alias: CF-00072) |
|---|---|---|---|---|
Vehicle (0.05 HCl & 0.1% Tween 80 in sterile water) | PO/QD × 28 | PO/QD × 28 | PO/QD × 28 | PO/QD × 28 |
Entinostat | 4 mg/kg, PO/QD × 28 | 4 mg/kg, PO/QD × 28 | 4 mg/kg, PO/QD × 28 | 4 mg/kg, PO/QD × 28 |
Vinorelbine | 4 mg/kg, IP/Q7D × 2 | 4 mg/kg, IP/Q7D × 2 | 4 mg/kg, IP/Q7D × 2 | 4 mg/kg, IP/Q7D × 2 |
Cyclophosphamide | 50 mg/kg, IP/QD × 1 | 50 mg/kg, IP/QD × 1 | 50 mg/kg, IP/QD × 1 | 50 mg/kg, IP/QD × 1 |
Doxorubicin | 2.5 mg/kg, IP/QD × 2 | 3 mg/kg, IP/QD × 2 | 2.5 mg/kg, IP/QD × 2 | 2.5 mg/kg, IP/QD × 2 |
Topotecan | 0.15 mg/kg, IP/QD × 5 | 0.15 mg/kg, IP/QD × 5 | 0.15 mg/kg, IP/QD × 5 | 0.15 mg/kg, IP/QD × 5 |
