Figure 8
Characteristics of m6A modification in the TCGA subtypes and tumor somatic mutation. (A) Survival analysis for high (120 cases) and low (250 cases) m6A-related score groups in the TCAG cohort by Kaplan–Meier curves (HR, 1.82 [1.27–2.62]); P < 0.0001, Log-rank text). (B) Variance in m6A-related scores among various TCGA-STAD molecular subtypes. The interquartile range of values was represented by the upper and lower ends of the boxes. The median values were represented by the lines in the boxes. The statistical P-values were represented by the asterisks (*P < 0.05; **P < 0.01; ***P < 0.001). (C) Variance in m6A-related scores among different MSI statuses, clinical stages, EBV infections, and clinical grades. The interquartile ranges of the values are represented by the upper and lower ends of the boxes. The median values are represented by the lines in the boxes. The statistical P-values are represented by the asterisks (*P < 0.05; **P < 0.01; ***P < 0.001). (D and E) The tumor somatic mutation of high scores (D) and low scores (E) is visualized by a waterfall plot. Each column represented an individual patient. The upper bar plot represents TMB, and the right numbers represent the mutation frequency.
