Figure 7

Photomicrograph of rat mammary gland tissues treated with different doses of BER/CH-NPs. (A) control group showing the presence of mammary lobules containing alveoli filled with milk secretion with normal histo-architecture. (B) 1 mg/kg BER/CH-NPs group shows the presence of blood vessel congestion (asterisk). (C) 5 mg/kg BER/CH-NPs group shows some milk alveoli with normal histo-architecture (black arrows), with some degenerated alveoli with minimal congestion of blood vessels (red arrow). (D) 10 mg/kg BER/CH-NPs group shows some enlarged alveoli due to alveolar boundary destructions (black arrows). (E) The 15 mg/kg BER/CH-NPs group showed the presence of some alveoli with apparent histo-architecture (black arrow) and many degenerated alveoli (blue arrow). (F) 20 mg/kg BER/CH-NPs group shows some alveoli with vacuolar degeneration of epithelium (black arrow) and some degenerated alveoli (blue arrow). (G) The 50 mg/kg BER/CH-NPs group shows epithelial cell debris within the alveolar (arrow) and ductular lumen. (H) 75 mg/kg BER/CH-NPs group shows complete alveolar degeneration and necrosis with mononuclear inflammatory cell infiltration. (I) The 100 mg/kg BER/CH-NPs group shows the presence of widely distributed interstitial mononuclear inflammatory cell infiltration (A). H&E. (× 100).