Figure 8

Photomicrograph of rat mammary gland tissues treated with different doses of CRE/CH-NPs. (a) 1 mg/kg CRE/CH-NPs group shows the presence of vacuolation of the alveolar epithelium (black arrows) with some degenerated alveoli (asterisk). (b) 5 mg/kg CRE/CH-NPs group shows minimal alveolar degeneration (A) with interstitial inflammatory cell infiltration. (c) 10 mg/kg CRE/CH-NPs group showing the presence of congestion of blood vessel (black arrow) and presence of blood vessel engorged with mononuclear inflammatory cells (blue arrow) and area of degenerated alveoli with mononuclear inflammatory cells infiltration (A). H&E. (× 100). (d) The 15 mg/kg, CRE/CH-NPs group, shows widely distributed alveolar degeneration and necrosis with mononuclear inflammatory cell infiltration (A). (e) 25 mg/kg CRE/CH-NPs group showed a wide area of degenerated milk alveoli with fibrosis (A). (f) 50 mg/kg CRE/CH-NPs group shows a large area of degenerated alveoli with massive mononuclear inflammatory cell infiltration (A) H&E. (× 100). (g) 75 mg/kg, CRE/CH-NPs group, showing the presence of a wide area of degenerated milk alveoli (A) with hemorrhage (black arrow) and fibrosis (red arrow) H&E. (× 400). (h) 100 mg/kg CRE/CH-NPs group showing the diffused area of alveolar necrosis with a massive number of mononuclear inflammatory cells infiltration H&E. (× 100).