Table 3 Top 20 hypomethylated genes associated with methadone exposure during pregnancy.
Column ID | Gene symbol | p-value | T-statistics | Beta difference (Methadone vs. control) |
|---|---|---|---|---|
cg21838924 | CLDN4 | 4.04E − 06 | − 7.27852 | − 0.549172 |
cg07304760 | SND1 | 3.17E − 05 | − 6.01537 | − 0.41437 |
cg27413643 | ANKRD27 | 0.000390315 | − 4.62903 | − 0.212522 |
cg22901347 | TNIK | 0.000769524 | − 4.27526 | − 0.510576 |
cg17330938 | PPM1H | 0.000886586 | − 4.20229 | − 0.348926 |
cg03643559 | IKZF5 | 0.0047426 | − 3.35226 | − 0.275393 |
cg23854988 | PHF21B | 0.0050101 | − 3.32468 | − 0.452111 |
cg05845592 | SULT1A1 | 0.00598517 | − 3.2353 | − 0.0920677 |
cg21463262 | ATP11A | 0.00651066 | − 3.19299 | − 0.33527 |
cg11986743 | B4GALT6 | 0.00808566 | − 3.08398 | − 0.318985 |
cg15365500 | UST | 0.0104887 | − 2.95275 | − 0.36672 |
cg27494055 | PCDHA10 | 0.0120504 | − 2.88255 | − 0.260356 |
cg15083522 | LRRC27 | 0.0122725 | − 2.8733 | − 0.315761 |
cg04922606 | FAM120B | 0.0125607 | − 2.86154 | − 0.382339 |
cg04924408 | SIAH3 | 0.0129081 | − 2.84771 | − 0.237718 |
cg19377607 | LRRC20 | 0.0131091 | − 2.83987 | − 0.286636 |
cg10240906 | BMP7 | 0.0142564 | − 2.79728 | − 0.34505 |
cg11251367 | FMN2 | 0.0154978 | − 2.75481 | − 0.338259 |
cg08242313 | DOCK10 | 0.0175354 | − 2.69182 | − 0.283316 |
cg06307915 | CETP | 0.0178121 | − 2.68381 | − 0.384047 |
