Table 6 Modified Tox Functions in Infants of MMOD Mothers.

Heart failure

Cardiotoxicity

3.39E⁻⁰³ to 4.01E⁻⁰¹

GRK5,SCN5A

Cardiac dilation

4.36E⁻⁰³ to 1.68E⁻⁰¹

NEDD4L,SCN5A

Cardiac enlargement

4.36E⁻⁰³ to 1.68E⁻⁰¹

NEDD4L,SCN5A

Tachycardia

1.3E⁻⁰² to 1.27E⁻⁰¹

SCN5A

Congenital heart anomaly

4.36E⁻⁰³ to 9.11E⁻⁰²

BMP7,MAML3,SCN5A

Cardiac dysfunction

3.43E⁻⁰² to 3.43E⁻⁰²

SCN5A

Cardiac arteriopathy

3.51E⁻⁰² to 3.93E⁻⁰²

ANKRD27,CETP,FMN2,LRRC20,SCN5A

Pulmonary hypertension

3.26E⁻⁰¹ to 3.26E⁻⁰¹

SCN5A

Cardiac damage

1.86E⁻⁰¹ to 1.86E⁻⁰¹

CAT

Cardiac inflammation

9.16E⁻⁰² to 9.16E⁻⁰²

CD80

Cardiac congestive cardiac failure

4.01E⁻⁰¹ to 4.01E⁻⁰¹

SCN5A

Cardiac arrythmia

4.36E⁻⁰³ to 1.89E⁻⁰¹

PIK3CG,SCN5A

Liver hyperplasia/Hyperproliferation

Hepatotoxicity

5.72E⁻⁰⁴ to 1.6E⁻⁰¹

ACOT1,ADAMTSL1,ANKRD27,AQP12A/AQP12B, ARID1B,ATP11A,ATP13A5,ATP2B2,ATP9A, AUTS2,B4GALT6,BLNK,BMP7,C1orf21,CAT, CAVIN1,CDH10,CETP,CLDN4,DIPK1B,DOCK10, DYSF,FMN2,GZF1,HLA-DQB2,HPS5,LRRC27, MAML3,MED16,MGAT5B,MYOM2,MZF1, NDUFA10,OR5H15,PCDHA10,PIK3CG,PLEKHA7, PPM1H,SCN5A,SEMA4B,SHLD2,SIAH3,SLC38A9,SND1,SNTG2,SORBS2,SULT1A1,TANC1,TESPA1, TNIK,TRPS1,WRAP73

Liver cirrhosis

3.96E⁻⁰¹ to 3.96E⁻⁰¹

CD80

Liver fibrosis

3.96E⁻⁰¹ to 3.96E⁻⁰¹

CD80

Increased levels of alkaline phosphatase

1.27E⁻⁰¹ to 1.27E⁻⁰¹

BMP7

Liver steatosis

2.1E⁻⁰¹ to 2.37E⁻⁰¹

ACOT1,CAT

Liver inflammation/hepatitis

2.37E⁻⁰¹ to 2.37E⁻⁰¹

ACOT1

Hepatocellular carcinoma

8.56E⁻⁰³ to 9.65E⁻⁰²

ACOT1,ARID1B,ATP2B2,ATP9A,AUTS2,BMP7, CAT,CETP,DIPK1B,MAML3,OR5H15,PCDHA10, SND1,SULT1A1,TNIK

Liver cholestasis

1.3E⁻⁰² to 2.82E⁻⁰²

CAT,MGST1,SULT1A1

Renal damage

Nephrotoxicity

5.93E⁻⁰² to 5.93E⁻⁰²

CD80

Kidney failure

9.51E⁻⁰² to 9.51E⁻⁰²

CD80,SCN5A

Renal necrosis/Cell death

1.16E⁻⁰¹ to 4.32E⁻⁰¹

ATP2B2,PAWR,SHLD2,TRPS1

Glomerular injury

1.6E⁻⁰¹ to 1.6E⁻⁰¹

CD80

Renal inflammation

1.6E⁻⁰¹ to 1.6E⁻⁰¹

CD80

Renal nephritis

1.6E⁻⁰¹ to 1.6E⁻⁰¹

CD80