Figure 5 | Scientific Reports

Figure 5

From: Identification of organs of origin of macrophages that produce presepsin via neutrophil extracellular trap phagocytosis

Figure 5

Identification of organs with MΦs producing P-SEP in a mouse model of sepsis. (a) Ly6c-positive cells were compared with positivity rate of Ly6C-positive M1 MΦs in each organ as M1 MΦs. M1 MΦs were the most abundant in the lungs of mice in the sham group, with a small number of M1 MΦs in the liver, spleen, and kidneys. Compared to the sham group, mice in the CLP group showed significantly increased Ly6C positivity in each organ, especially markedly in the lungs and liver. Each dot represents one mouse. (b) Comparing P-SEP expression in M1 MΦs in each organ between sham and CLP groups, intracellular P-SEP expression in each organ was lower in sham group mice, while P-SEP expression in M1 MΦs in lungs, liver, and spleen was significantly increased in CLP group mice. Each dot represents one mouse. All differences denoted by asterisks were subjected to two-tailed Student’s t-tests. Values are presented as mean ± SD (n = 5). **p < 0.01. P-SEP, presepsin; M1 MΦs, M1 macrophage.

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