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Figure 4

From: Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity

Figure 4

Experimental Assessment in STZ + HFD-Induced C57BL/6 Mice. (a) Hematoxylin & Eosin (H&E) staining in reducing liver adipose tissue damage for diabetes models. (b) Sirius red (SR) staining on liver tissue fibrosis for NASH models. (c) Alanine transaminase (ALT) level. (d) Aspartate aminotransferase (AST) level. (e) NAFLD Activity Score (NAS). (f) Liver total cholesterol (TC) level. (g) Liver triglyceride (TG) level. (h) Fibrosis rates level. (i) Low-density lipoprotein (LDL) level. (j) High-density lipoprotein (HDL) level. (***p < 0.001; **p < 0.01; *p < 0.05. See Supplementary Table 4–6 for details.)

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