Table 3 Association between serum chloride and 90-day and 365-day all-cause mortality in COPD critically ill patients.

	Model 1		Model 2		Model 3		Model 4	P
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)
90d-mortality
Serum Chloride (continuous)	0.99 (0.97, 1.00)	0.020	0.98 (0.97, 0.99)	0.003	0.98 (0.97, 0.99)	< 0.001	0.96 (0.94, 0.98)	< 0.001
Serum Chloride (categorical)
Q1	Ref		Ref		Ref		Ref
Q2	0.66 (0.53, 0.81)	< 0.001	0.65 (0.52, 0.80)	< 0.001	0.66 (0.53, 0.81)	< 0.001	0.64 (0.51, 0.80)	< 0.001
Q3	0.60 (0.49, 0.74)	< 0.001	0.59 (0.48, 0.73)	< 0.001	0.61 (0.49, 0.75)	< 0.001	0.60 (0.47, 0.77)	< 0.001
Q4	0.72 (0.59, 0.89)	0.002	0.67 (0.54, 0.82)	< 0.001	0.64 (0.52, 0.78)	< 0.001	0.54 (0.41, 0.71)	< 0.001
P for trend		0.001		< 0.001		< 0.001		< 0.001
365d-mortality
Serum Chloride (continuous)	0.98 (0.97, 0.99)	< 0.001	0.97 (0.96, 0.98)	< 0.001	0.97 (0.96, 0.98)	< 0.001	0.96 (0.94, 0.97)	< 0.001
Serum Chloride (categorical)
Q1	Ref		Ref		Ref		Ref
Q2	0.61 (0.51, 0.73)	< 0.001	0.60 (0.50, 0.72)	< 0.001	0.60 (0.51, 0 .72)	< 0.001	0.60 (0.49, 0.72)	< 0.001
Q3	0.60 (0.50, 0.71)	< 0.001	0.58 (0.49, 0.69)	< 0.001	0.60 (0.50, 0.72)	< 0.001	0.61 (0.50, 0.75)	< 0.001
Q4	0.64 (0.54, 0.76)	< 0.001	0.59 (0.50, 0.71)	< 0.001	0.57 (0.48, 0.68)	< 0.001	0.52 (0.42, 0.66)	< 0.001
P for trend		< 0.001		< 0.001		< 0.001		< 0.001

Model 1: no adjusted.
Model 2: adjusted for age, gender, and weight.
Model 3: adjusted for age, gender, weight, WBC, RBC, platelet, hemoglobin, RDW, hypertension, diabetes, and heart failure.
Model 4: adjusted for age, gender, weight, WBC, RBC, platelet, hemoglobin, RDW, hypertension, diabetes, heart failure, myocardial infarction, CKD, stroke, hyperlipidemia, sodium, potassium, calcium, glucose, PT, PTT, BUN, sCR, SOFA, APS III, SIRS, SAPS II, SBP, and DBP.
HR: hazard ratio; CI confidence interval.

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