Table 2 Genotypic and allelic distribution of the MSH3 and MSH6 genetic variant and its association with risk of lung cancer overall and according to tumor histology.

From: Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation

Genotype rs26279 G > A (MSH3)

Controls (500) N (%)

Cases (500) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (500) N (%)

Cases (500) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

OVERALL

AA

355 (71.0)

369 (73.8)

1.00 (Reference)

 

TT

407 (81.4)

432 (86.4)

1.00 (Reference)

 

GA

127 (25.4)

117 (23.4)

0.90 (0.67–1.21)

0.52

GT

85 (17)

68 (13.6)

0.75 (0.53–1.07)

0.12

GG

18 (3.6)

14 (2.8)

0.75 (0.36–1.56)

0.45

GG

8 (1.6)

0 (0)

0

0.99

G(Allele)

837

855

  

GG (Allele)

899

932

  

A(Allele)

163

145

  

TT (Allele)

101

68

  

MAF

0.163

0.145

  

MAF

0.101

0.068

  

χ2 = 1.81; df = 2

0.03

χ2 = 10.63; df = 2

0.10

Dominant model

Dominant model

AA

355 (71.0)

369 (73.8)

1.00 (Reference)

 

TT

407 (81.4)

432 (86.4)

1.00 (Reference)

 

GA + GG

145 (29.0)

131 (26.2)

0.89 (0.67–1.18)

0.42

GT + GG

93 (18.6)

68 (13.6)

0.69 (0.49–0.98)

0.03

     

Recessive model

     

GT + GG

93 (18.6)

68 (13.6)

1.00 (Reference)

 
     

TT

407 (81.4)

432(86.4)

1.43 (1.01–2.03)

0.03

Genotype rs26279 G > A (MSH3)

Controls (500) N (%)

Cases (203) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (500) N (%)

Cases (203) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

ADCC

AA

355 (71.0)

152 (74.9)

1.00 (Reference)

 

TT

407 (81.4)

177 (87.2)

1.00 (Reference)

 

GA

127 (25.4)

48 (23.7)

0.99 (0.66–1.49)

0.97

GT

85 (17)

26 (12.8)

0.60 (0.36–1.02)

0.06

GG

18 (3.6)

3 (1.4)

0.40 (0.10–1.49)

0.17

GG

8 (1.6)

0 (0)

0

0.99

Dominant model

Dominant model

AA

355 (71.0)

152 (74.8)

1.00 (Reference)

 

TT

407 (81.4)

177 (87.2)

1.00 (Reference)

 

GA + GG

145 (29.0)

51 (25.2)

0.92 (0.61–1.37)

0.69

GT + GG

93 (18.6)

26 (12.8)

0.56 (0.34–0.95)

0.03

     

Recessive model

     

GT + GG

93 (18.6)

26 (12.8)

1.00 (Reference)

 
     

TT

407 (81.4)

177 (87.2)

1.75 (1.05–2.93)

0.03

Genotype rs26279 G > A (MSH3)

Controls (500) N (%)

Cases (205) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (500) N (%)

Cases (205) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

SQCC

AA

355 (71.0)

146 (71.2)

1.00 (Reference)

 

TT

407 (81.4)

172 (83.9)

1.00 (Reference)

 

GA

127 (25.4)

50 (24.3)

0.94 (0.64–1.37)

0.75

GT

85 (17)

33 (16.1)

1.01 (0.64–1.58)

0.96

GG

18 (3.6)

9 (4.3)

1.04 (0.45–2.42)

0.91

GG

8 (1.6)

0 (0)

0

0.99

Dominant model

Dominant model

AA

355 (71.0)

146 (71.3)

1.00 (Reference)

 

TT

407 (81.4)

172 (83.9)

1.00 (Reference)

 

GA + GG

145 (29.0)

59 (28.7)

0.95 (0.66–1.37)

0.80

GT + GG

93 (18.6)

33 (16.1)

0.91 (0.58–1.42)

0.69

     

Recessive model

     

GT + GG

93 (18.6)

33 (16.1)

1.00 (Reference)

 
     

TT

407 (81.4)

172 (83.9)

1.09 (0.70–1.70)

0.69

Genotype rs26279 G > A (MSH3)

Controls (500) N (%)

Cases (84) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (500) N (%)

Cases (84) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

SCLC

AA

355 (71.0)

65 (77.4)

1.00 (Reference)

 

TT

407 (81.4)

75 (89.3)

1.00 (Reference)

 

GA

127 (25.4)

18 (21.4)

0.80 (0.45–1.42)

0.44

GT

85 (17)

9(10.7)

0.63 (0.30–1.33)

0.22

GG

18 (3.6)

1 (1.2)

0.25 (0.03–2.02)

0.19

GG

8 (1.6)

0

0

0.99

Dominant model

Dominant model

AA

355 (71.0)

65 (77.4)

1.00 (Reference)

 

TT

407 (81.4)

75 (89.3)

1.00 (Reference)

 

GA + GG

145 (29.0)

19 (22.6)

0.72 (0.41–1.26)

0.25

GT + GG

93 (18.6)

9(10.7)

0.57 (0.27–1.21)

0.14

     

Recessive model

     

GT + GG

93 (18.6)

9(10.7)

1.00 (Reference)

 
     

TT

407 (81.4)

75 (89.3)

1.73 (0.83–3.62)

0.14

  1. aAdjusted Odds ratios, 95% confidence intervals and their corresponding p-values were calculated by logistic regression analysis after adjusting for age, gender.
  2. bTwo-sided χ2 test for either genotype distribution or allelic frequencies between the cases and controls. The number in bold indicates the significant values in the table.
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