Table 3 Relationship of different MSH3 and MSH6 genotypes with the smoking status of cases and controls.

From: Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation

Genotype rs26279 G > A (MSH3)

Controls (449) N (%)

Cases (398) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (449) N (%)

Cases (398) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

SMOKERS

AA

313 (69.7)

292 (73.4)

1.00 (Reference)

 

TT

371 (82.7)

341 (85.7)

1.00 (Reference)

 

GA

118 (26.3)

95 (23.9)

0.87 (0.63–1.19)

0.40

GT

70 (15.6)

57 (14.3)

0.91 (0.62–1.34)

0.64

GG

18 (4.0)

11 (2.7)

0.58 (0.26–1.30)

0.19

GG

8 (1.7)

0 (0)

0

0.99

Dominant model

Dominant model

AA

313 (69.7)

292 (73.4)

1.00 (Reference)

 

TT

371 (82.6)

341 (85.7)

1.00 (Reference)

 

GA + GG

136 (30.3)

106 (26.6)

0.83 (0.61–1.13)

0.24

GT + GG

78 (17.4)

57 (14.3)

0.82 (0.56–1.19)

0.30

     

Recessive model

     

GT + GG

78 (17.3)

57 (14.3)

1.00 (Reference)

 
     

TT

371 (82.7)

341 (85.7)

1.21 (0.83–1.77)

0.30

Genotype rs26279 G > A (MSH3)

Controls (51) N (%)

Cases (102) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (51) N (%)

Cases (102) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

NON SMOKERS

AA

42 (82.4)

77 (75.5)

1.00 (Reference)

 

TT

36 (70.6)

91 (89.3)

1.00 (Reference)

 

GA

9 (17.6)

22 (21.6)

1.47 (0.57–3.75)

0.41

GT

15 (29.4)

11 (10.7)

0.31 (0.12–0.78)

0.01

GG

0 (0)

3 (2.9)

2.48E + 07

0.99

GG

0

0

0

0.99

Dominant model

Dominant model

AA

42 (82.4)

77 (75.5)

1.00 (Reference)

 

TT

36 (70.6)

91 (89.3)

1.00 (Reference)

 

GA + GG

9 (17.6)

25 (24.5)

1.65 (0.65–4.15)

0.28

GT + GG

15 (29.4)

11 (10.7)

0.31 (0.12–0.78)

0.01

     

Recessive model

     

GT + GG

15 (29.4)

11 (10.7)

1.00 (Reference)

 
     

TT

36 (70.6)

91 (89.3)

3.22 (1.26–8.18)

0.01

Genotype rs26279 G > A (MSH3)

Controls (323) N (%)

Cases (155) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (323) N (%)

Cases (155) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

LIGHT SMOKERS

AA

222 (68.7)

117 (75.6)

1.00 (Reference)

 

TT

269 (83.3)

131 (84.5)

1.00 (Reference)

 

GA

88 (27.3)

34 (21.9)

0.75 (0.47–1.20)

0.23

GT

49 (15.2)

24 (15.5)

1.06 (0.61–1.82)

0.82

GG

13 (4.0)

4 (2.5)

0.39 (0.10–1.44)

0.16

GG

5 (1.5)

0

0

0.99

Dominant model

Dominant model

AA

222 (68.7)

117 (75.5)

1.00 (Reference)

 

TT

269 (83.3)

131 (84.5)

1.00 (Reference)

 

GA + GG

101 (31.3)

38 (24.5)

0.70 (0.45–1.10)

0.13

GT + GG

54 (16.7)

24 (15.5)

0.96 (0.56–1.64)

0.89

     

Recessive model

     

GT + GG

54 (16.7)

24 (15.5)

1.00 (Reference)

 
     

TT

269 (83.3)

131 (84.5)

1.03 (0.60–1.77)

0.89

Genotype rs26279 G > A (MSH3)

Controls (126) N (%)

Cases (243) N (%)

AOR (95% CI)a

pb

Genotype rs3136228 557 G > T (MSH6)

Controls (126) N (%)

Cases (243) N (%)

AOR (95% CI)a

pb

Co-dominant model

Co-dominant model

HEAVY SMOKERS

AA

91 (72.2)

175 (72.0)

1.00 (Reference)

 

TT

102 (80.9)

210 (86.4)

1.00 (Reference)

 

GA

30 (23.9)

61 (25.2)

1.05 (0.63–1.75)

0.83

GT

21 (16.7)

33 (13.6)

0.77 (0.42–1.41)

0.41

GG

5 (3.9)

7 (2.8)

0.75 (0.23–2.45)

0.64

GG

3 (2.4)

0

0

0.99

Dominant model

Dominant model

AA

91 (72.3)

175 (72.1)

1.00 (Reference)

 

TT

102 (80.9)

210 (86.4)

1.00 (Reference)

 

GA + GG

35 (27.7)

68 (27.9)

1.01 (0.62–1.63)

0.96

GT + GG

24 (19.1)

33 (13.6)

0.68 (0.38–1.22)

0.19

     

Recessive model

     

GT + GG

24 (19.1)

33 (13.6)

1.00 (Reference)

 
     

TT

102 (80.9)

210 (86.4)

1.46 (0.81–2.61)

0.19

  1. aAdjusted Odds ratios, 95% confidence intervals and their corresponding p-values were calculated by logistic regression analysis after adjusting for age, gender.
  2. bTwo-sided χ2 test for either genotype distribution or allelic frequencies between the cases and controls. The number in bold indicates the significant values in the table.
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