Table 1 Clinical characteristics of hypertensives patients with and without initial endothelial impairment.

From: Effect of early endothelial function improvement on subclinical target organ damage in hypertensives

Variables

ALL(n = 456)

Impaired group (n = 180)

Normal group (n = 276)

P value

Female, n (%)

214 (46.93%)

66 (36.67%)

148 (53.62%)

0.001

Age (years)

61.11 ± 11.67

62.65 ± 10.96

60.11 ± 12.03

0.023

Current smoking [n (%)]

135 (29.61%)

71 (39.44%)

64 (23.19%)

 < 0.001

Drinking [n (%)]

53 (11.62%)

23 (12.78%)

30 (10.87%)

0.534

Duration of EH (months)

3 (0–10)

4 (1–10)

2 (0–8)

0.001

Diabetes mellitus [n (%)]

58 (12.72%)

34 (18.89%)

24 (9.06%)

0.002

BMI (kg/m2)

24.25 ± 3.02

24.59 ± 2.72

24.03 ± 3.18

0.053

SBP (mmHg)

151.04 ± 11.13

151.82 ± 12.54

150.53 ± 10.10

0.248

DBP (mmHg)

85.05 ± 12.05

85.13 ± 12.29

85.00 ± 11.90

0.908

Heart rate (bp)

72.13 ± 9.07

71.59 ± 9.78

72.47 ± 8.58

0.314

TBil (μmol/L)

14.40 ± 6.26

14.75 ± 6.64

14.18 ± 6.00

0.355

ALT (U/L)

24 (17–34)

24 (18–35)

23 (17–33)

0.120

LDH (U/L)

177.26 ± 45.61

181.13 ± 54.81

174.81 ± 37.57

0.164

Uric acid (μmol/L)

349.03 ± 89.85

361.12 ± 96.59

340.99 ± 84.30

0.028

eGFR (mL/min/1.73m2)

89.48 ± 14.83

87.38 ± 14.28

90.87 ± 15.05

0.018

Total cholesterol (mmol/L)

4.99 ± 1.10

4.94 ± 1.04

5.02 ± 1.13

0.458

HDL-C (mmol/L)

1.37 ± 0.40

1.38 ± 0.40

1.37 ± 0.40

0.896

LDL-C (mmol/L)

3.04 ± 0.97

2.94 ± 0.93

3.11 ± 0.98

0.074

FSG (mmol/L)

5.77 ± 1.26

5.91 ± 1.34

5.68 ± 1.20

0.065

CIMT (cm)

0.06 ± 0.01

0.06 ± 0.01

0.06 ± 0.01

0.075

UACR (mg/g)

6.99 (3.82–13.10)

6.61 (3.33–13.90)

7.47 (4.10–13.05)

0.419

LVMI (g/m2)

81.61 ± 19.54

84.80 ± 23.23

79.91 ± 17.06

0.047

ACEI/ARBs [n (%)]

237 (51.97%)

92 (51.11%)

145 (52.54%)

0.766

β-blockers [n (%)]

116 (25.44%)

33 (18.33%)

83 (27.07%)

0.005

Calcium channel blockers [n (%)]

235 (51.54%)

97 (53.89%)

138 (50.00%)

0.417

Diuretics [n (%)]

145 (31.80%)

65 (36.11%)

80 (28.99%)

0.110

Statin [n (%)]

169 (37.06%)

91 (50.56%)

78 (28.26%)

 < 0.001

FMD (%)

9.40 ± 6.57

3.75 ± 3.01

13.08 ± 5.58

 < 0.001

  1. Data are expressed as means ± SD or median (25th–75th).
  2. EH essential hypertension, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TBil total bilirubin, ALT alanine aminotransferase, LDH lactate dehydrogenase, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, FSG fasting serum glucose, CIMT carotid intima-media thickness, UACR urinary albumin to creatinine ratio, LVMI left ventricular mass index, ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker, FMD flow-mediated dilation.
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