Table 2 Comparison of genomic alterations identified in plasma basal and tissue samples, only patients with both samples available are included.

From: Building on the clinical applicability of ctDNA analysis in non-metastatic pancreatic ductal adenocarcinoma

 

Plasma basal

Tissue

Patient ID

Altered gene

Variant gene

Variant protein

VAF

Classification

Altered gene

Variant gene

Variant protein

VAF

Classification

P1

None

    

CDKN1B (CNV)

CNV

  

Pathogenic

P2

TP53

c.537 T > A

p.His179Gln

0.07

Pathogenic

TP53

c.537 T > A

p.His179Gln

8.89

Pathogenic

P9

KRAS

c.35G > T

p.Gly12Val

0.07

Pathogenic

KRAS

c.35G > T

p.Gly12Val

4.37

Pathogenic

P10

TP53

c.992_993insT

p.Gln331HisfsTer6

0.19

Likely pathogenic

None

    

P11

TP53

c.701A > G

p.Tyr234Cys

0.18

Pathogenic

     
     

KRAS

c.35G > T

p.Gly12Val

17.74

Pathogenic

     

RNF43

c.1179_1180insT

p.Ala394CysfsTer49

5.27

Likely pathogenic

     

NOTCH2

c.2755C > T

p.Pro919Ser

49.82

VUS

     

KRAS

c.35G > A

p.Gly12Asp

11.13

Pathogenic

     

ARID1A

c.3980_3981insCGCA

p.Gln1327HisfsTer12

7.52

Likely pathogenic

     

POLE

c.1453A > G

p.Ile485Val

49.61

VUS

P12

None

    

None

    

P14

None

    

TP53

c.842A > G

p.Asp281Gly

20.21

Pathogenic

P13

None

    

KRAS

c.35G > T

p.Gly12Val

17.42

Pathogenic

P22

TP53

c.659A > G

p.Tyr220Cys

0.15

Pathogenic

     

APC

c.3920delT

p.Ile1307LysfsTer14

1.1

Likely pathogenic

     
     

KRAS

c.35G > T

p.Gly12Val

19.49

Pathogenic

     

TP53

c.700 T > A

p.Tyr234Asn

29.93

Likely pathogenic

P23

TP53

c.662_663delAG

p.Glu221AlafsTer3

0.08

Likely pathogenic

TP53

c.662_663delAG

p.Glu221AlafsTer3

5.97

Likely pathogenic

     

KRAS

c.35G > A

p.Gly12Asp

4.02

Pathogenic

     

RB1

c.1850delG

p.Gly617ValfsTer6

6.65

Likely pathogenic

P24

TP53

c.992_993insT

p.Gln331HisfsTer6

0.17

Likely pathogenic

     
     

TP53

c.768delA

p.Leu257TrpfsTer88

26.18

Likely pathogenic

     

KRAS

c.35G > T

p.Gly12Val

14.86

Pathogenic

     

MSH6

c.2562G > C

p.Lys854Asn

33.89

VUS

     

CCNE1 (CNV)

CNV

  

Pathogenic

P25

KRAS

c.35G > T

p.Gly12Val

0.08

Pathogenic

KRAS

c.35G > T

p.Gly12Val

26.53

Pathogenic

     

TP53

c.524G > A

p.Arg175His

22.42

Pathogenic

  1. Genomic alterations found in both, plasma and tissue samples are highlighted in bold.
  2. APC adenomatous polyposis coli, ARID1A AT-rich interaction domain 1A, CCNE1 cyclin E1, CDKN1B cyclin dependent kinase inhibitor 1B, KRAS KRAS proto-oncogene, GTPase, MSH6 mutS homolog6, NOTCH2 notch receptor 2, POLE DNA polymerase epsilon, catalytic subunit, RB1 RB transcriptional corepresor 1, RNF43 ring finger protein 43, TP53 tumor protein p53, VAF variant allele frequency, VUS variant of unknown significance.
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