Figure 2 | Scientific Reports

Figure 2

From: GelMA loaded with platelet lysate promotes skin regeneration and angiogenesis in pressure ulcers by activating STAT3

Figure 2

PL stimulates beneficial healing characteristics of HDFs and HUVECs. (A) CCK8 assay shows HDFs viability at 24 h and 48 h after PL treatment. (B) Cell migration is represented as the ratio of the scratched wound area of HDFs with 24 h PL treatment to the area without treatment (0 h) and (C) typical photographs of wound healing assay of HDFs with different concentration gradient PL treatment for 24 h. (D) Tube networks formation of HUVECs in the control and different PL groups (scale bar = 200 μm, C–D). (E) The tube formation ability of HUVECs was improved significantly. (F) The relative mRNA expression of genes of HDFs with different PL treatments via qPCR. (G) and (H) Protein bands and their protein expression in HDFs with different PL treatments via WB analysis. All the above data are expressed as mean ± SD.*p < 0.05 or **p < 0.01 vs. control group by one-way ANOVA followed by LSD multiple comparison. We repeated the experiments three times to ensure the accuracy of the experiments.

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