Figure 4

Distinctive trades of intestinal microbiome prior to treatment are associated with better responding rates to therapy with 1,8-Cineol. A Relative abundance comparisons between responders and non-responders groups, B differences in beta diversity of microbiome depending on responder’s status, C indicator species associated with patient group responding to therapy computed via LEfSe taxa analysis, D selected depiction of genus Prevotella species abundances in the responders and non-responders groups. Patients were defined as responders in case of none or less otorrhea and pain symptoms were presented.