Table 3 Hazard ratios for CV and composite events of BNP levels.

From: Plasma B-type natriuretic peptide is independently associated with cardiovascular events and mortality in patients with chronic kidney disease

 

No. of events

Model 1

Model 2

Model 3

Model 4

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

CV events

158

        

 Low of BNP

52

Reference

Reference

Reference

Reference

 Middle of BNP

41

2.25 (1.49, 3.40)

 < 0.01

1.31 (0.85, 2.02)

0.22

1.15 (0.74, 1.80)

0.53

1.00 (0.63, 1.58)

0.99

 High of BNP

65

5.23 (3.60, 7.60)

 < 0.01

2.96 (1.96, 4.46)

 < 0.01

2.28 (1.46, 3.56)

 < 0.01

1.72 (1.06, 2.79)

0.03

 Log BNP (per 1-log unit increment)

–

1.81 (1.60, 2.04)

 < 0.01

1.54 (1.33, 1.79)

 < 0.01

1.41 (1.19, 1.66)

 < 0.01

1.26 (1.05, 1.52)

0.02

Composite events

248

        

 Low of BNP

77

Reference

Reference

Reference

Reference

 Middle of BNP

74

2.96 (2.15, 4.08)

 < 0.01

1.52 (1.09, 2.13)

0.01

1.22 (0.86, 1.72)

0.27

1.10 (0.77, 1.57)

0.62

 High of BNP

97

6.01 (4.42, 8.17)

 < 0.01

2.74 (1.96, 3.83)

 < 0.01

1.84 (1.28, 2.63)

 < 0.01

1.54 (1.04, 2.27)

0.03

 Log BNP (per 1-log unit increment)

–

1.92 (1.74, 2.12)

 < 0.01

1.52 (1.35, 1.71)

 < 0.01

1.29 (1.13, 1.47)

 < 0.01

1.21 (1.04, 1.40)

0.01

  1. Model 1: Crude.
  2. Model 2: Adjusted for age, sex, diabetes mellitus, dyslipidemia, smoking, systolic blood pressure, and BMI.
  3. Model 3: Adjusted for model 2 plus prior CVDs, malignancy, CRP, hemoglobin, eGFR, and serum albumin.
  4. Model 4: Adjusted for model 3 plus LVEF, LAD, and LVMI.
  5. CV cardiovascular, BNP B-type natriuretic peptide, HR hazard ratio, CI confidence interval, CVD cardiovascular disease, SBP systolic blood pressure, BMI body mass index, CRP C-reactive protein, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, LAD left atrial diameter, LVMI left ventricular mass index.
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