Figure 3 | Scientific Reports

Figure 3

From: Elucidating Microglial Heterogeneity and Functions in Alzheimer’s Disease Using Single-cell Analysis and Convolutional Neural Network Disease Model Construction

Figure 3

9 hub genes identified as significant biomarkers for AD. (A), The optimal rank was 3 as the cophenetic coefficient started firstly decreasing. (B), GSVA scores of 9 hub genes in the 3 NMF subgroups. (C), Heat map of genes across 3 subgroups. (D), Heat map of immune infiltration in 3 subgroups. (E), GSVA scores of immune infiltration in 3 subgroups. (F–N), Box plot analysis of 9 hub genes expression in AD and HC groups in bulk RNA-seq. (F), USP3. (G), ANKS1B. (H), RPL41. (I), PDE4D. (J), TPT1. (K), ARHGAP22. (L), RPS15. (M), NRXN3. (N), HLA-B. AD, Alzheimer's Disease; NMF, Non-negative Matrix Factorization; HC, healthy control. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Back to article page