Table 2 Analytes (serum proteins) significantly correlated to MRI-PDFF, ALT and AST at baseline.

Beta-glucuronidase

GUSB

6.34E − 14

4.79E − 10

1.43E − 13

5.35E − 12

6.69E − 09

1.38E − 07

Triggering receptor expressed on myeloid cells 2

TREM2

1.43E − 10

5.42E − 07

4.86E − 11

1.47E − 09

2.41E − 14

7.98E − 13

Adenylosuccinate synthetase isozyme 1

ADSS1

3.39E − 10

8.54E − 07

1.66E − 37

3.59E − 35

2.87E − 37

3.55E − 35

Tetratricopeptide repeat protein 36

TTC36

2.91E − 09

5.49E − 06

1.09E − 31

1.27E − 29

8.71E − 23

4.75E − 21

Triggering receptor expressed on myeloid cells 2

TREM2

7.83E − 09

1.18E − 05

3.52E − 18

1.78E − 16

2.02E − 24

1.25E − 22

Liver carboxylesterase 1

CES1

4.02E − 08

5.07E − 05

7.77E − 13

2.80E − 11

6.44E − 18

2.59E − 16

Growth hormone receptor

GHR

2.69E − 07

0.00029

1.36E − 09

3.61E − 08

2.88E − 06

3.74E − 05

Fructose-bisphosphate aldolase B

ALDOB

4.19E − 07

0.000396

1.19E − 54

1.29E − 51

4.74E − 55

3.98E − 52

Fructose-1,6-bisphosphatase 1

FBP1

5.17E − 07

0.000434

2.41E − 61

3.64E − 58

2.48E − 61

4.69E − 58

Isocitrate dehydrogenase [NADP] cytoplasmic

IDH1

7.32E − 07

0.000553

2.63E − 53

1.99E − 50

3.45E − 52

1.53E − 49

Argininosuccinate lyase

ASL

1.04E − 06

0.000713

1.94E − 71

1.46E − 67

8.65E − 76

6.54E − 72

Protein CREG1

CREG1

1.50E − 06

0.000942

0.000628

0.005445

0.000845

0.005064

D-3-phosphoglycerate dehydrogenase

PHGDH

1.77E − 06

0.000988

6.09E − 24

4.65E − 22

1.74E − 20

8.36E − 19

Homogentisate 1,2-dioxygenase

HGD

3.75E − 06

0.001888

1.26E − 53

1.06E − 50

5.52E − 55

4.17E − 52

Retinol-binding protein 5

RBP5

1.01E − 05

0.00476

1.42E − 33

1.98E − 31

4.04E − 41

6.78E − 39

Acyl-CoA-binding domain-containing protein 4

ACBD4

1.07E − 05

0.00476

6.58E − 24

4.97E − 22

8.73E − 23

4.75E − 21

3-oxo-5-beta-steroid 4-dehydrogenase

AKR1D1

1.23E − 05

0.005162

1.87E − 44

7.45E − 42

5.84E − 35

6.13E − 33

Alcohol dehydrogenase 1A

ADH1A

1.49E − 05

0.005797

2.87E − 52

1.81E − 49

2.93E − 50

9.23E − 48

Aldo–keto reductase family 1 member C4

AKR1C4

1.53E − 05

0.005797

5.87E − 37

1.20E − 34

3.07E − 37

3.69E − 35

Fumarylacetoacetase

FAH

1.67E − 05

0.006015

6.57E − 58

8.28E − 55

1.48E − 50

4.88E − 48

NADP-dependent malic enzyme

ME1

1.76E − 05

0.006048

1.81E − 32

2.28E − 30

1.65E − 46

4.15E − 44

Aminoacylase-1

ACY1

2.37E − 05

0.0064

1.90E − 64

4.78E − 61

1.49E − 62

3.74E − 59

Phosphoserine aminotransferase

PSAT1

2.25E − 05

0.0064

1.44E − 54

1.37E − 51

6.86E − 53

3.46E − 50

UDP-N-acetylhexosamine pyrophosphorylase

UAP1

2.33E − 05

0.0064

2.41E − 25

2.04E − 23

1.76E − 22

9.52E − 21

Triggering receptor expressed on myeloid cells 2

TREM2

2.02E − 05

0.0064

2.01E − 17

9.61E − 16

1.36E − 25

9.26E − 24

Apolipoprotein F

APOF

2.23E − 05

0.0064

8.12E − 08

1.68E − 06

0.000373

0.002551

Heme oxygenase 1

HMOX1

2.04E − 05

0.0064

0.000116

0.001279

0.002612

0.012552

Pterin-4-alpha-carbinolamine dehydratase

PCBD1

2.62E − 05

0.006821

2.80E − 52

1.81E − 49

1.06E − 56

1.14E − 53

Alcohol dehydrogenase 1C

ADH1C

2.94E − 05

0.007401

1.13E − 50

6.10E − 48

1.67E − 52

7.87E − 50

Glycine amidinotransferase, mitochondrial

GATM

3.51E − 05

0.007915

4.47E − 41

1.30E − 38

1.66E − 58

2.10E − 55

Alcohol dehydrogenase 4

ADH4

3.54E − 05

0.007915

3.95E − 40

1.07E − 37

2.29E − 36

2.63E − 34

Lambda-crystallin homolog

CRYL1

3.71E − 05

0.007915

7.63E − 37

1.48E − 34

1.39E − 33

1.28E − 31

L-lactate dehydrogenase A chain

LDHA

3.83E − 05

0.007915

5.13E − 23

3.56E − 21

4.49E − 29

3.53E − 27

Beta-enolase

ENO3

3.87E − 05

0.007915

7.46E − 09

1.81E − 07

4.85E − 07

7.26E − 06

Dihydropteridine reductase

QDPR

4.33E − 05

0.008402

2.31E − 43

8.74E − 41

4.18E − 38

5.64E − 36

Receptor-type tyrosine-protein phosphatase eta

PTPRJ

4.64E − 05

0.008556

2.15E − 08

4.82E − 07

8.28E − 08

1.44E − 06

Interleukin-1 receptor antagonist protein

IL1RN

4.90E − 05

0.00882

1.07E − 06

1.80E − 05

4.34E − 07

6.55E − 06

S-adenosylmethionine synthase isoform type-1

MAT1A

5.13E − 05

0.009013

3.37E − 49

1.70E − 46

8.58E − 47

2.32E − 44

Glutathione S-transferase A1

GSTA1

5.74E − 05

0.009639

2.41E − 36

4.23E − 34

1.38E − 39

2.01E − 37

L-xylulose reductase

DCXR

6.24E − 05

0.010246

5.83E − 63

1.10E − 59

3.81E − 56

3.60E − 53

Beta-hexosaminidase subunit beta

HEXB

7.41E − 05

0.011664

0.000104

0.001161

3.27E − 07

5.08E − 06

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

ENPP7

8.39E − 05

0.012734

5.98E − 09

1.48E − 07

9.49E − 16

3.48E − 14

Acid sphingomyelinase-like phosphodiesterase 3a

SMPDL3A

8.42E − 05

0.012734

0.003155

0.020022

0.009658

0.034317

Serine hydroxymethyltransferase, cytosolic

SHMT1

0.000118

0.017301

9.21E − 37

1.70E − 34

5.93E − 42

1.25E − 39

Protein tyrosine phosphatase type IVA 1

PTP4A1

0.000119

0.017301

1.43E − 25

1.23E − 23

6.41E − 24

3.78E − 22

Aldehyde dehydrogenase, mitochondrial

ALDH2

0.000129

0.018355

4.89E − 26

4.45E − 24

7.64E − 25

5.02E − 23

Homeodomain-interacting protein kinase 3

HIPK3

0.000134

0.018768

0.002568

0.017037

0.00937

0.033616

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

ALDH6A1

0.000143

0.019339

8.20E − 27

7.95E − 25

2.13E − 21

1.07E − 19

Ribonucleoside-diphosphate reductase subunit M2 B

RRM2B

0.000142

0.019339

1.94E − 08

4.40E − 07

2.72E − 10

6.57E − 09

Ribonuclease UK114

RIDA

0.000152

0.019539

2.67E − 36

4.48E − 34

5.35E − 41

8.61E − 39

Cytosolic endo-beta-N-acetylglucosaminidase

ENGASE

0.000153

0.019539

3.26E − 11

1.02E − 09

2.85E − 09

6.24E − 08

Retinal dehydrogenase 2

ALDH1A2

0.000152

0.019539

4.42E − 05

0.00054

0.000181

0.001388

Sorbitol dehydrogenase

SORD

0.000188

0.02364

7.32E − 35

1.13E − 32

4.01E − 35

4.33E − 33

Cysteine-rich motor neuron 1 protein:Extracellular domain

CRIM1

0.000204

0.024106

1.08E − 24

8.52E − 23

1.96E − 32

1.68E − 30

Visinin-like protein 1

VSNL1

0.000204

0.024106

1.23E − 11

4.09E − 10

3.15E − 07

4.91E − 06

Oxysterol-binding protein 1

OSBP

0.000263

0.028447

0.000352

0.003332

0.002432

0.011914

Fructose-bisphosphate aldolase C

ALDOC

0.00027

0.028729

9.73E − 37

1.75E − 34

3.63E − 41

6.24E − 39

Glutathione S-transferase A1

GSTA1

0.000274

0.02876

9.10E − 38

2.02E − 35

1.12E − 41

2.21E − 39

Hsp90alpha

HSP90AA1

0.000312

0.031473

7.57E − 34

1.10E − 31

1.73E − 34

1.72E − 32

Espin

None

0.000335

0.032079

6.81E − 26

5.99E − 24

5.99E − 21

2.94E − 19

Valacyclovir hydrolase

BPHL

0.000331

0.032079

7.05E − 06

0.000104

1.22E − 05

0.000134

Formimidoyltransferase-cyclodeaminase

FTCD

0.000344

0.032531

4.44E − 28

4.47E − 26

3.53E − 34

3.47E − 32

Enoyl-CoA hydratase, mitochondrial

ECHS1

0.000382

0.035621

2.31E − 33

3.18E − 31

7.19E − 43

1.65E − 40

Leukocyte cell-derived chemotaxin-2

LECT2

0.000386

0.035623

0.007285

0.037007

0.009114

0.032979

UDP-glucose 6-dehydrogenase

UGDH

0.000499

0.044609

8.03E − 40

1.96E − 37

2.25E − 49

6.80E − 47

Cathepsin D

CTSD

0.000502

0.044609

4.68E − 06

7.12E − 05

4.99E − 12

1.36E − 10

Afamin

AFM

0.000532

0.045667

2.61E − 06

4.23E − 05

3.45E − 06

4.39E − 05

Cathepsin Z

CTSZ

0.000524

0.045667

0.001161

0.009041

0.000117

0.000963

NADPH–cytochrome P450 reductase

POR

0.000558

0.046196

4.40E − 52

2.56E − 49

8.90E − 59

1.35E − 55

3-hydroxybutyrate dehydrogenase type 2

BDH2

0.000554

0.046196

2.63E − 25

2.21E − 23

2.44E − 26

1.74E − 24

Lysosomal alpha-glucosidase

GAA

0.000568

0.046196

7.72E − 12

2.59E − 10

2.22E − 17

8.61E − 16

Hydroxymethylglutaryl-CoA synthase, mitochondrial

HMGCS2

0.000591

0.0475

1.39E − 14

5.51E − 13

4.92E − 19

2.08E − 17